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laronidase  (BioMarin Inc)

 
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    BioMarin Inc laronidase
    Laronidase, supplied by BioMarin Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/laronidase/product/BioMarin Inc
    Average 90 stars, based on 1 article reviews
    laronidase - by Bioz Stars, 2026-02
    90/100 stars

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    ( A ) IDUA activity in 5-week MPS IH pellets untreated or treated with <t>laronidase</t> (mean ± SEM from 5 MPS IH and 5 MPS IH + rhIDUA pellets): MPS IH, 10.95 ± 4.08 nmol/mg/h; MPS IH + rhIDUA, 290.1 ± 38.72 nmol/mg/h. ** P < 0.01 by paired, 2-sided t test. The red dotted line represents the HD mean. ( B ) Relative GAG content in 5-week MPS IH pellets treated with laronidase compared with untreated (mean ± SEM from 5 MPS IH + rhIDUA compared with 5 untreated pellets): MPS IH + rhIDUA, 0.36 ± 0.11. ** P < 0.01 by paired, 2-sided t test. ( C ) Histological images of Alcian blue– and Sirius red–stained (upper panels) and von Kossa–stained (bottom panels) sections of MPS IH pellets from the same patient untreated or treated with laronidase. Scale bars: 100 μm.
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    ( A ) IDUA activity in 5-week MPS IH pellets untreated or treated with <t>laronidase</t> (mean ± SEM from 5 MPS IH and 5 MPS IH + rhIDUA pellets): MPS IH, 10.95 ± 4.08 nmol/mg/h; MPS IH + rhIDUA, 290.1 ± 38.72 nmol/mg/h. ** P < 0.01 by paired, 2-sided t test. The red dotted line represents the HD mean. ( B ) Relative GAG content in 5-week MPS IH pellets treated with laronidase compared with untreated (mean ± SEM from 5 MPS IH + rhIDUA compared with 5 untreated pellets): MPS IH + rhIDUA, 0.36 ± 0.11. ** P < 0.01 by paired, 2-sided t test. ( C ) Histological images of Alcian blue– and Sirius red–stained (upper panels) and von Kossa–stained (bottom panels) sections of MPS IH pellets from the same patient untreated or treated with laronidase. Scale bars: 100 μm.
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    ( A ) IDUA activity in 5-week MPS IH pellets untreated or treated with <t>laronidase</t> (mean ± SEM from 5 MPS IH and 5 MPS IH + rhIDUA pellets): MPS IH, 10.95 ± 4.08 nmol/mg/h; MPS IH + rhIDUA, 290.1 ± 38.72 nmol/mg/h. ** P < 0.01 by paired, 2-sided t test. The red dotted line represents the HD mean. ( B ) Relative GAG content in 5-week MPS IH pellets treated with laronidase compared with untreated (mean ± SEM from 5 MPS IH + rhIDUA compared with 5 untreated pellets): MPS IH + rhIDUA, 0.36 ± 0.11. ** P < 0.01 by paired, 2-sided t test. ( C ) Histological images of Alcian blue– and Sirius red–stained (upper panels) and von Kossa–stained (bottom panels) sections of MPS IH pellets from the same patient untreated or treated with laronidase. Scale bars: 100 μm.
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    ( A ) IDUA activity in 5-week MPS IH pellets untreated or treated with <t>laronidase</t> (mean ± SEM from 5 MPS IH and 5 MPS IH + rhIDUA pellets): MPS IH, 10.95 ± 4.08 nmol/mg/h; MPS IH + rhIDUA, 290.1 ± 38.72 nmol/mg/h. ** P < 0.01 by paired, 2-sided t test. The red dotted line represents the HD mean. ( B ) Relative GAG content in 5-week MPS IH pellets treated with laronidase compared with untreated (mean ± SEM from 5 MPS IH + rhIDUA compared with 5 untreated pellets): MPS IH + rhIDUA, 0.36 ± 0.11. ** P < 0.01 by paired, 2-sided t test. ( C ) Histological images of Alcian blue– and Sirius red–stained (upper panels) and von Kossa–stained (bottom panels) sections of MPS IH pellets from the same patient untreated or treated with laronidase. Scale bars: 100 μm.
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    Image Search Results


    ( A ) IDUA activity in 5-week MPS IH pellets untreated or treated with laronidase (mean ± SEM from 5 MPS IH and 5 MPS IH + rhIDUA pellets): MPS IH, 10.95 ± 4.08 nmol/mg/h; MPS IH + rhIDUA, 290.1 ± 38.72 nmol/mg/h. ** P < 0.01 by paired, 2-sided t test. The red dotted line represents the HD mean. ( B ) Relative GAG content in 5-week MPS IH pellets treated with laronidase compared with untreated (mean ± SEM from 5 MPS IH + rhIDUA compared with 5 untreated pellets): MPS IH + rhIDUA, 0.36 ± 0.11. ** P < 0.01 by paired, 2-sided t test. ( C ) Histological images of Alcian blue– and Sirius red–stained (upper panels) and von Kossa–stained (bottom panels) sections of MPS IH pellets from the same patient untreated or treated with laronidase. Scale bars: 100 μm.

    Journal: JCI Insight

    Article Title: Modeling skeletal dysplasia in Hurler syndrome using patient-derived bone marrow osteoprogenitor cells

    doi: 10.1172/jci.insight.173449

    Figure Lengend Snippet: ( A ) IDUA activity in 5-week MPS IH pellets untreated or treated with laronidase (mean ± SEM from 5 MPS IH and 5 MPS IH + rhIDUA pellets): MPS IH, 10.95 ± 4.08 nmol/mg/h; MPS IH + rhIDUA, 290.1 ± 38.72 nmol/mg/h. ** P < 0.01 by paired, 2-sided t test. The red dotted line represents the HD mean. ( B ) Relative GAG content in 5-week MPS IH pellets treated with laronidase compared with untreated (mean ± SEM from 5 MPS IH + rhIDUA compared with 5 untreated pellets): MPS IH + rhIDUA, 0.36 ± 0.11. ** P < 0.01 by paired, 2-sided t test. ( C ) Histological images of Alcian blue– and Sirius red–stained (upper panels) and von Kossa–stained (bottom panels) sections of MPS IH pellets from the same patient untreated or treated with laronidase. Scale bars: 100 μm.

    Article Snippet: Pellets treated with the recombinant human L-IDUA were supplemented with 5 mg/mL laronidase (Aldurazyme, Sanofi) for the entire culture period.

    Techniques: Activity Assay, Staining